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The Importance of Behavioral Phenotyping in Rodent Models of Parkinson’s Disease
Start Date: 4/17/2019Start Time: 1:30 PM
End Date: 4/17/2019End Time: 3:00 PM

Event Description:
The Importance of Behavioral Phenotyping in Rodent Models of Parkinson’s Disease

Sheila Flemming will speak. Abstract: Parkinson’s disease is characterized pathologically by the degeneration of dopamine neurons in the substantia nigra and the development of alpha-synuclein containing Lewy bodies in neurons and neurites. Clinical diagnosis is based on the development of motor symptoms that include bradykinesia, rigidity, resting tremor, and postural instability. However, in addition to the cardinal motor signs there are a host of non-motor symptoms that can develop and significantly worsen quality of life for patients. The non-motor symptoms in PD involve a wide range of behavioral systems including olfactory, cognitive, neuropsychiatric, and autonomic. Many of these symptoms are reported to occur in the early, prodromal period of the disease making them attractive targets for biomarker development and potential neuroprotective therapies. Our research focuses on identifying both motor and non-motor impairments in rodent models of PD and incorporating them as necessary outcome measures in preclinical drug testing. 

https://www.purdue.edu/hhs/cerebbral/

Contact Information:
Name: Sandy Snyder
Phone: 765-494-3796
Email: snyder33@purdue.edu
Fleming
Additional Information
When: April 17
Time: 1:30-3:00 p.m.
Where: Stewart Center, Rm. 214

https://www.purdue.edu/hhs/cerebbral/

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